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Rebecca J Brown Selected Research

Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy)

6/2022Characterization and Clinical Association of Autoantibodies Against Perilipin 1 in Patients with Acquired Generalized Lipodystrophy.
1/2022Endogenous Leptin Concentrations Poorly Predict Metreleptin Response in Patients With Partial Lipodystrophy.
11/2021Effects of metreleptin in patients with lipodystrophy with and without baseline concomitant medication use.
10/2021Leptin Attenuates Cardiac Hypertrophy in Patients With Generalized Lipodystrophy.
2/2021Apolipoprotein CIII and Angiopoietin-like Protein 8 are Elevated in Lipodystrophy and Decrease after Metreleptin.
1/2021Effect of Leptin Therapy on Survival in Generalized and Partial Lipodystrophy: A Matched Cohort Analysis.
1/2020Metabolomic Analysis of the Effects of Leptin Replacement Therapy in Patients with Lipodystrophy.
11/2019Comorbidities and Survival in Patients With Lipodystrophy: An International Chart Review Study.
1/2018A Novel Generalized Lipodystrophy-Associated Progeroid Syndrome Due to Recurrent Heterozygous LMNA p.T10I Mutation.
1/2018Long-term effectiveness and safety of metreleptin in the treatment of patients with generalized lipodystrophy.
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Rebecca J Brown Research Topics

Disease

37Lipodystrophy
06/2022 - 09/2012
27Insulin Resistance
06/2022 - 09/2012
16Congenital Generalized Lipodystrophy (Berardinelli-Seip Congenital Lipodystrophy)
06/2022 - 08/2014
10Hypertriglyceridemia
01/2022 - 09/2012
9Obesity
01/2022 - 06/2012
8Type 2 Diabetes Mellitus (MODY)
06/2022 - 08/2010
8Type 1 Diabetes Mellitus (Autoimmune Diabetes)
01/2017 - 07/2008
5Hyperglycemia
01/2020 - 09/2012
4Hyperandrogenism
01/2021 - 09/2012
4Diabetes Mellitus
01/2019 - 01/2016
3Neoplasms (Cancer)
05/2022 - 08/2009
3Liver Diseases (Liver Disease)
01/2021 - 04/2010
3Non-alcoholic Fatty Liver Disease
01/2021 - 01/2017
3Dyslipidemias (Dyslipidemia)
01/2020 - 09/2012
3Metabolic Syndrome (Dysmetabolic Syndrome X)
01/2016 - 09/2012
3Weight Loss (Weight Reduction)
03/2014 - 06/2012
3Weight Gain
06/2012 - 08/2010
2Hypoglycemia (Reactive Hypoglycemia)
06/2022 - 04/2011
2Body Weight (Weight, Body)
01/2022 - 04/2016
2Donohue Syndrome
01/2022 - 11/2013
2Metabolic Diseases (Metabolic Disease)
10/2021 - 01/2016
2Diabetes Complications
01/2020 - 01/2017
2Hyperinsulinism (Hyperinsulinemia)
01/2020 - 01/2017
2Familial Partial Lipodystrophy (Dunnigan Syndrome)
01/2020 - 01/2019
2Hyperlipidemias (Hyperlipidemia)
01/2017 - 12/2016
2Fatty Liver
06/2014 - 09/2012
1Mycoses (Diseases, Fungus)
06/2022
1Pain (Aches)
06/2022
1Pancreatitis
06/2022
1Diabetic Ketoacidosis (Ketoacidosis, Diabetic)
06/2022
1Malignant Mesothelioma
05/2022
1Thyroid Neoplasms (Thyroid Cancer)
01/2022
1Cardiomegaly (Heart Hypertrophy)
10/2021
1Acquired Partial Lipodystrophy
06/2021
1Cardiovascular Diseases (Cardiovascular Disease)
08/2019
1Proteinuria
04/2019
1Kidney Diseases (Kidney Disease)
04/2019
1Albuminuria
04/2019
1Thyroid Nodule (Nodule, Thyroid)
01/2019
1Papillary Thyroid Cancer
01/2019
1Inflammation (Inflammations)
01/2018
1Acanthosis Nigricans
01/2018
1Hyperphagia (Overeating)
01/2018
1Hepatomegaly
01/2018
1Progeria (Hutchinson Gilford Syndrome)
01/2018

Drug/Important Bio-Agent (IBA)

32LeptinIBA
01/2022 - 09/2012
27metreleptinIBA
01/2022 - 08/2014
17Insulin (Novolin)FDA Link
06/2022 - 07/2008
12Glucose (Dextrose)FDA LinkGeneric
01/2022 - 05/2012
12Triglycerides (Triacylglycerol)IBA
10/2021 - 09/2014
10Insulin ReceptorIBA
01/2022 - 09/2012
6Biomarkers (Surrogate Marker)IBA
06/2022 - 08/2009
4AutoantibodiesIBA
06/2022 - 09/2012
41-dodecylpyridoxal (PLD)IBA
01/2022 - 05/2015
4LipidsIBA
11/2021 - 09/2014
3Hemoglobins (Hemoglobin)IBA
06/2022 - 04/2011
3Testosterone (Sustanon)FDA Link
01/2022 - 01/2017
3Lipoprotein Lipase (Diacylglycerol Lipase)IBA
02/2021 - 03/2017
3B-insulinIBA
11/2018 - 01/2016
3HDL CholesterolIBA
01/2018 - 06/2014
3AntibodiesIBA
01/2016 - 01/2009
2Hormones (Hormone)IBA
01/2022 - 05/2014
2AndrogensIBA
01/2022 - 01/2017
2Apolipoprotein C-IIIIBA
02/2021 - 01/2016
2Thyroid HormonesIBA
01/2021 - 01/2020
2Gonadotropin-Releasing Hormone (GnRH)FDA Link
01/2021 - 01/2017
2CarbohydratesIBA
01/2020 - 04/2011
2Blood Glucose (Blood Sugar)IBA
01/2020 - 01/2014
2Pharmaceutical PreparationsIBA
01/2016 - 08/2009
2Exenatide (Byetta)FDA Link
10/2014 - 01/2014
2Biological ProductsIBA
05/2014 - 08/2009
2Sweetening Agents (Sweeteners)IBA
06/2012 - 08/2010
1Perilipin-1IBA
06/2022
1Sodium-Glucose Transport ProteinsIBA
06/2022
1B7-H1 AntigenIBA
05/2022
1Steroid 11-beta-Hydroxylase (11 beta-Hydroxylase)IBA
01/2022
1Insulin-Like PeptidesIBA
01/2022
1Growth Hormone (Somatotropin)IBA
01/2022
1Androstenedione (4 Androstene 3,17 dione)IBA
01/2022
1SteroidsIBA
01/2022
1Complement Factor D (Factor D)IBA
06/2021
1Complement System Proteins (Complement)IBA
06/2021
1AdipokinesIBA
04/2021
1Angiopoietin-Like Protein 8IBA
02/2021
1Apolipoproteins AIBA
02/2021
1Apolipoproteins C (ApoC)IBA
02/2021
1Adrenergic Agents (Adrenergic Drugs)IBA
01/2021
1Nonesterified Fatty Acids (NEFA)IBA
01/2020
1DeuteriumIBA
01/2020
1Glycerol (Glycerine)FDA LinkGeneric
01/2020
1HDL LipoproteinsIBA
08/2019
1ChylomicronsIBA
08/2019
1Lipoproteins (Lipoprotein)IBA
08/2019
1Insulin-Like Growth Factor I (IGF-1)IBA
01/2019
1Lamin Type A (Lamin A)IBA
01/2018
1Angiopoietin-Like Protein 3IBA
03/2017

Therapy/Procedure

19Therapeutics
05/2022 - 01/2009
3Glycemic Control
01/2019 - 03/2014
2Injections
01/2020 - 12/2016
1Aftercare (After-Treatment)
01/2018